Zebrafish larvae readily absorb compounds from the surrounding water, which is a great advantage when it comes to determining the effects of certain drugs or other substances. For example, they are an ideal subject when testing novel anticonvulsants or proconvulsants in epilepsy research.
Zebrafish larvae have the great advantage of being small enough to test in multi-well plates, making them suitable for high-throughput screening. A controlled testing environment allows for effective and efficient protocols.
An observation chamber offers just that. The DanioVision Observation Chamber provides a complete testing environment: it contains all necessary hardware on the inside, keeping everything else out so you are in control over the experimental conditions. Its innovative design guarantees a reliable image for tracking each individual larva.
Screening compounds benefits greatly from 96-well plate setups, as this allows for high-throughput testing. DanioVision is a great tool for accommodating such research.
“Exposing 2 to 4 dpf fish to moderate concentrations of water-soluble proconvulsants, such as pentylenetetrazol (PTz), is sufficient to dramatically increase locomotion that can very easily be measured using the DanioVision system”, according to Richard Baines (University of Manchester, UK).
Read more about Richard Baines' research in this blog post: http://www.noldus.com/blog/seizing-fish-high-throughput-screen-novel-antiepileptic-drugs.
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